Leucine
C₆H₁₃NO₂·131.175 g/mol·Amino Acids·CID 6106
Amino AcidEssentialBCAA
An essential BCAA and the strongest activator of the mTOR protein synthesis pathway. The most abundant amino acid in muscle proteins. Its isobutyl side chain makes it strongly hydrophobic. Key supplement in sports nutrition.
IUPAC: (2S)-2-amino-4-methylpentanoic acid
Molecular Structure
Molecular Propertiesmass · H-bonds · stereo
Molecular Weight
131.170g/mol
Exact Mass
131.094629Da
Monoisotopic Mass
131.094629Da
XLogP
-1.5
Polar Surface Area
63.3Ų
Complexity
101
Formal Charge
0
H-Bond Donors
2
H-Bond Acceptors
3
Rotatable Bonds
3
Heavy Atoms
9
Stereo Centers
1
Bond Stereo
0
Drug-Likeness (Lipinski's Rule of Five)
✓ 131.2 g/mol
MW ≤ 500
✓ -1.5
LogP ≤ 5
✓ 2
H-bond donors ≤ 5
✓ 3
H-bond acceptors ≤ 10
Passes all rules — good oral bioavailability predicted
Chemical IdentifiersSMILES · InChI
InChI
InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
Constituent Elements
Isomers8 compounds with formula C₆H₁₃NO₂
(2S,3S)-2-amino-3-methylpentanoic acid
CID 6306 · 131.2 g/mol
6-aminohexanoic acid
CID 564 · 131.2 g/mol
(2R)-2-amino-4-methylpentanoic acid
CID 439524 · 131.2 g/mol
(2S,3R)-2-amino-3-methylpentanoic acid
CID 99288 · 131.2 g/mol
(2S)-2-aminohexanoic acid
CID 21236 · 131.2 g/mol
2-amino-3-methylpentanoic acid
CID 791 · 131.2 g/mol
2-morpholin-4-ylethanol
CID 61163 · 131.2 g/mol
(2S)-2-azaniumyl-4-methylpentanoate
CID 7045798 · 131.2 g/mol